Partnership Studies
Partnership studies are studies that are operated by partners within the SEAICRN. Partnership studies are consistent with the mission statement, vision and values of the SEAICRN. The studies contribute to the SEAICRN and have an important outcome to South East Asia.
Current partners of the SEAICRN include institutions from Thailand (Queen Sirikit National Institute of Child Health; Siriraj Hospital; Sappasitthiprasong Hospital and Chiang-Rai Hospital), Viet Nam (Hospital for Tropical Diseases; Children's Hospital#1; Children's Hospital #2; Hue General Hospital; National Hospital for Tropical Diseases; National Hospital for Pediatrics), Indonesia (Dr. Wahidin Soedirohusodo Hospital; Dr. Sardjito Hospital; Cipto Mangunkusumo Hospital; INA Respond), Mahidol Oxford Research Unit, Oxford University Clinical Research Unit, FHI 360, SSS, NIH/NIAID, Wellcome Trust.
1. A randomized, placebo-controlled, double-blind trial of intravenous magnesium sulfate for the management of severe HFMD with autonomic nervous system dysregulation in Vietnamese children
Primary Objective: To evaluate the effects of MgSO4 on conrol of hypertension and progression to severe disease (shock, respiratory compromise or death) in children with severe HFMD and ANS dysregulation.
Status: Subjects being enrolled
2. A randomized, open-label, comparative study of the effectiveness of itraconazole versus amphotericin B in the induction treatment of penicillosis in HIV-infected adults
Primary Objective: To compare the efficacy of Itraconazole and amphotericin B in the acute-phase treatment of penicilliosis as assessed by the absolute risk of death during the first 2 weeks of therapy.
Status: Subjects being enrolled
3. Lovastatin for adult patients with dengue: protocol for a RCT
Primary Objective: To assess the safety of a short course of lovastatin therapy used early in the course of acute dengue infections
Status: Subjects being enrolled
4. Intensified treatment with high dose Rifampicin and Levofloxacin compared to a standard treatment for adult patients with TB meningitis
Primary Objective: To test the study hypothesis that intensifying the induction phase of treatment of TB meningitis will result in reduced mortality.
Status: Subjects being enrolled
5. Cryptodex: A randomized, double-blind, placebo-controlled Phase III trial of adjunctive dexamethasone in HIV infected patients with Cryptococcal meninigitis
Primary Objective: To investigate the effect of dexamethasone adjunctive therapy on 10-week survival in adult HIV infected patients with cryptococcal meningitis
Status: Subjects being enrolled