SEAICRN Studies
SEAICRN Studies are supported by the Network and receive direct and/or indirect (in-kind) support from the SEAICRN. They utilize the network's resources that can either be financial, operational, technical, scientific or administrative.
1. An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis in Southeast Asia
Primary Objective: To determine the causes of community-acquired sepsis and severe sepsis in adults and pediatrics across South East Asia.
Status: Ongoing - Subjects being enrolled.
Case Report Form: available upon request. Please contact PI, Dr Direk Limmathurotsakul
direk@tropmedres.ac
2. Molecular Epidemiology of Pathogens Associated with Community-acquired sepsis and severe sepsis in Southeast Asia using Whole Genome Sequencing
Primary Objective: To define molecular epidemiology of pathogens that causes community-acquired sepsis and severe sepsis in adult and pediatric subjects across South East Asia using WGS analysis.
Status: Active
3. The Influenza Exome Sequencing Study - A study of the genetic determinants of severe influenza
Primary Objective: To identify host genetic variants associated with severe influenza.
4. Non-influenza etiologies of acute respiratory illness in Southeast Asia
Primary Objective: To determine the viral and bacterial etiologies of ARIs in patients with lower respiratory tract infection in South East Asia.
Status: Publication under review
The following studies are derived from the SEA001 study "Effect fo double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial" published in the
BMJ
SEA001-A Further analysis of the virology data of SEA001
SEA001-B Analysis of the pharmacology data of SEA001
Primary Objective: To use oseltamivir and oseltamivir carboxylate plasma concentration measurements measurements and relevant clinical study data to perform a population pharmacokinetic-pharmacodynamic analysis.
SEA001-C Deep sequencing of virological samples from SEA001 and SEA032 combined with analysis of the immunological response
SEA032 "Antiviral treatment in adults and children with novel influenza A (H1N1) respiratory tract infection - a clinical, virological and pharmacokinetic study"
Primary Objective: To obtain insight into evolution of influenza viruses during human infection by identification and characterization of genetic variations and evolutionary mechanisms that support immune escape and adaptation to the human host.
SEA001-D Serologic re-analysiss of sera from H5N1 patients
Primary Objective: To define cut-off points for recent influenza A H5N1 infection using a novel protein microarray for serological profiling of humoral immune responses.